ML 209

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(±)-ML 209 (compound 4n) 是一种二苯基丙酰胺，一种视黄酸相关的孤儿受体 RORγ 拮抗剂，IC50 为 1.1 μM。(±)-ML 209 在 HEK293t 细胞中抑制 RORγt 转录活性，IC50 为 300 nM。(±)-ML 209 抑制细胞中 RORγt 的转录活性，但不抑制 RORα。(±)-ML 209 选择性抑制鼠 Th17 细胞分化，而不影响幼稚 CD4+ T 细胞分化为Th1 和调节性 T 细胞。

(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of na?ve CD4+ T cells into other lineages, including Th1 and regulatory T cells.

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Nuclear Receptor/Transcription Factor

ROR

ROR

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1334526-14-5

441.52

C25H31NO6

>98% (HPLC)

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C(CC(=O)N1C[C@@H](C)C[C@@H](C)C1)(C2=C(OC)C=C(OC)C=C2O)C=3C=C4C(=CC3)OCO4

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(-20℃)

With Ice Pack

≥ 2 years